Diabetes mellitus is now known to be linked to an increased risk of osteoporosis-related fractures and osteoarthritis in recent years. Sesamin indicum L has been shown to reduce bone damage in the past. However, it is still unknown if Sesamin indicum L may prevent diabetics against osteoporosis. The impact of Sesamin indicum L on bone oxidative stress and turnover indicators in diabetic rats is investigated in this study.Diabetic is induced by streptozotocin (STZ). For 8 weeks, diabetic Sprague Dawley rats (n = 6) were given one of three treatments through gavage: saline (control), metformin (1000mg/kg bw), or extract of Sesamin indicum L (100mg/kg bw). As a normal control group, a group of healthy rats was used. ELISA assays were used to assess blood levels of insulin, oxidative stress, and bone turnover indicators. Sesamin indicum L treatment of diabetic rats resulted in considerably higher insulin and osteocalcin levels than diabetic control rats. By increasing osteogenesis and reducing bone oxidative stress, Sesamin indicum L may be able to prevent diabetic osteoporosis. These data support the use of Sesamin indicum L as an osteoporosis treatment in diabetic patients.

The aim of the present study was to establish the physico-chemical properties in sea waters of Tuticorin and Rameswaram district during Post Monsoon Season. These marine ecosystems have become the privileged receptacle of pollution because of the anthropogenic development which discharge wastewaters in many points of marine coasts. Such situation requires the establishment of a sustainable strategy for monitoring and protecting the environment. In order to preserve these coastal environments and their resources, four distinct study sites were chosen and their physico-chemical properties were analyzed. The findings revealed that pollution has a significant impact on study site 2 during Post Monsoon Season. These results may be used as a potential test analysis to track sea water characteristics at specific locations.

The effects of Sophorae Fructus extracts on bone loss in diabetic rats caused by streptozotocin (STZ) were studied. For 8 weeks, rats were given Sophorae Fructus extracts orally. Diabetic Sprague Dawley rats (n=6) were administered one of three treatments through gavage for 8 weeks: saline (control), metformin (1000mg/kg/day), or Sophorae Fructus extract (500mg/kg/day). Diabetic rats treated with Sophorae Fructus had significantly greater insulin and osteocalcin levels than diabetic control rats. The benefits of Sophorae Fructus extracts on bone loss prevention or therapy in diabetic rats appear to be related to a decrease in bone turnover. These findings back up the usage of Sophorae Fructus in diabetic individuals as an osteoporosis therapy.

From literature survey reveals that ovarian carcinoma (Cancer) is the most lethal gynecologic malignancy in females all over the world. Most of the patients who are suffering from ovarian carcinoma clinical complete remissions are obtained through combinations of cyto-reductive surgery and chemotherapy. From this review given us an overview of the origin of ovarian cancer, history of chemotherapeutic regimens and also focused on chemotherapeutic agents which are useful in the treatment of ovarian cancer. For neoadjuvant chemotherapy taxanes are agent which is used widely. This review article adds better advances in medical field may be based on the better understanding and better choice of drugs regimens and better control of cost in routine practice; which opens the new path for neoadjuvant chemotherapy which proves a better option in ovarian cancer treatment in future.

The purpose of the present research study was to achieve successful delivery specifically to the colon, based on polysaccharides hydroxyl propyl methyl cellulose K4M (HPMC K4M), Xanthan gum, croscarmellose sodium (CCS) and microcrystalline cellulose as a compression coat over a core tablet of Prednisolone. The drug delivery system was based on the In-vitro evaluation system. In this study, each polysaccharide, along with microcrystalline cellulose, was used as a compression coating polymer and a combination of polysaccharides in the ratio of 1:1,1:2, 1:3, 2:1, 2:2, and 2:3 was evaluated using In-vitro methods. The prepared tablets were evaluated for hardness, friability, weight variation, and drug content uniformity, and it was found that the results obtained complied with the official standards. The cumulative percentage release of Prednisolone after 12 hours in a pH 6.8 phosphate buffer was capable of maintaining the core tablet containing Prednisolone throughout this condition mimicking mouth to colon transit, according to in-vitro experiments. The kinetic analyses of the release confirmed that it followed the Korsmeyer-Peppas paradigm. The formulation having HPMC K4M, in particular, had an improved dissolving profile and bioavailability, indicating it a potential carrier for drug delivery to the colon.