Ascorbic acid is one of the critical antioxidants. Consequently, It avoids spread of chain responses which activated by free radicals. It is also has the capability to prevention of lipid peroxidation and decreasing of oxidative harm, which hurtful for the layer and damage spermatozoa DNA. The objective of this study was to determine the impact of ascorbic acid (AA, 40mg/kg BW) on semen overhaul and plasma testosterone level in male rabbits every day for 12 weeks. Results showed that treatment with ascorbic acid caused significant increase in the testosterone level, reaction time, ejaculate volume, sperm concentration, total sperm output, sperm motility (%), total motile sperm per ejaculate (TMS), packed sperm volume (PSV), total functional sperm fraction (TFSF), normal and live sperm and semen initial fructose. While, dead sperm, initial hydrogen ion concentration (pH) and TBARS were decreased. In addition, relative weights of testes (RTW) and epididymis (REW) were increased compared to control group.

Some bacteria has acquired resistance to antibiotics, the antibacterial activity of plant products have gained special interest in the recent decades. Artemisia herba-alba Asso is medicinal plant used in Libyan traditional medicine. The methicillin resistant Staphylococcus aureus (MRSA) is multi-drug resistant and exhibited high level of resistance to common β-lactam antibiotics. In this study the in vitro antibacterial activity of the plant essential oil against standard Staphylococcus aureus ATCC 25923 (SSA) and extended spectrum β-lactamase producer methicillin resistant Staphylococcus aureus (ESBP-MRSA) was investigated. Hydro-distillation with Clevenger-type apparatus was used to extract the essential oil of aerial parts of Artemisia herba alba and Disc diffusion and Agar dilution methods were used to assess the antibacterial activity and the minimum inhibitory concentration (MIC), respectively. The essential oil the plant showed high activity as antibacterial agent against both standard and clinical bacteria with inhibition zones of 31.3mm and 29.5mm, respectively. The MIC was shown as 3.125mg/ml against tested clinical ESBP-MRSA. Also the essential oil showed higher anti ESBP-MRSA than antibiotics references used. The results of this study showed an important promising antibacterial activity of essential oil of Artemisia herba-alba against ESBP-MRSA, and suggest that the essential oil could be used as alternative to Gentamicin and Vancomycin.

Standardization of herbal formulation is important so as to assess the standard, purity, safety and efficacy of the drugs. Most of the normal system of drugs is effective but they lack of standardization. So there's a requirement to develop a standardization technique. During this research is an effort to guage “Hingwashtak churna” an Ayurvedic formulation for its internal control parameters. In house Hingwashtak churna preparation was evaluated by performing Organoleptic evaluation, Physicochemical evaluation, Physical characteristics and Phytochemical screening. it had been observed that the set parameters were wont to standardize the “Hingwashtak churna” these findings are going to be help towards establishing pharmacopoeia standards for crude drugs also as for formulation which are gaining relevance in research on traditional medicinal system.

Siddha system of the medicine is the most primitive among all other medical system which was practiced in India particularly in Tamilnadu. In siddha system of traditional medicine minerals and animal product are used as main drug to treat various dreadful diseases. Standardization of siddha preparations is of most important task to establishing the active components of drug for its biological activity. The main aim of the study was to evaluate the Biochemical analysis of the trial drug Sarvanoi Arirasa chendhuram and it indicates the presence of calcium, Sulphate, chloride, ferrous iron, unsaturation compound, aminoacid which revealed the enhancement of therapeutic action in vadha, pittha and kaphadiseases.

The Aim of this work is to the development and evaluation of Nanosponges drug delivery system of Losartan by using solvent evaporation method. Losartan is a BCS class II drug, having a half-life of 1.5-2.5 hours, which wasn’t suitable for maintaining constant plasma concentrations. So Losartan was formulated as a Nanosponge formulation for effective drug release. FTIR spectroscopy is used to identify organic, polymeric and inorganic materials of the drug in these nanosponges. Scanning electron microscopy used to identify the spherical nature of the nanosponge in all variations. The formulation F9 has better results than remaining formulations. F9 formulation shows entrapment efficiency 97.02%, drug release 98.15% in 12 hour, and follows zero order with super case II transport mechanism.