Thermosensitive liposomes (TSLs) are the optimistic class of nanomedicine which has the potential of providing site specific delivery of anticancer drugs. They are more effective when combined with local hyperthermia or high intensity focused ultrasound in treatment of cancer, by enhancing the vascular permeability of the drug and its transport to the target site without damaging the normal tissues and they also enhance the permeability of lipid bilayers. The two important elements which has to be considered that affects efficacy are, kinetics of release and stability of plasma, thereby to improve properties the new formulations are aimed at. The usage of lysolipids and thermosensitive polymers which are naturally and synthetically derived demonstrates the temperature sensitization of liposomes. This article summarizes about the materials and methods used in the preparation of thermosensitive liposomes and also various biomedical applications of TSLs. The main objective of this article is to introduce the recent advances used in the thermosensitive liposomes like traditional thermosensitive liposomes which is composed of lipids that undergoes transition from gel-to-liquid phase at a certain point above the physiological temperature. Multi-functional thermosensitive liposomes are another approach which is used to enhance the delivery of anticancer drugs. Thermosensitive liposomes when combined with magnetic resonance guided drug delivery for external targeting, becomes an unique feature in nanotechnology in the field of medicine.

The major goal of the current investigation is to create and assess a multi-herbal ointment with antifungal activity. Ointments made from ethanolic extracts of Azadirachta indica, Allium sativum and Psidium guajava were tested for their physical and chemical properties, including their antifungal efficacy. Different extract concentrations, such as 2 percent, 4 percent and 6 percent w/w, were used to make ointments utilising the fusion process with emulsifying ointment as the basis. The formulations' physicochemical characteristics, such as loss of drying, pH, spreadability, extrudability and diffusion studies, were then examined, and the findings were good. Additionally, the formulations were stable at 4°C, 25°C and 37°C. Additionally, using the agar diffusion method and miconazole (5 percent w/w), polyherbal formulations were tested for their anti-fungal efficacy against Trichophyton rubrum and Trichophyton mentagrophytes.

In any habitat many things can vary from day to day or season to season such that an individual may seem to be bombarded with challenges. These may vary from routine changes such as osmotic adjustments to changing salinity in an estuary or seasonal ranges in temperature to major perturbations following a fire or human disturbance. Endocrinology is a science developed as a subset of physiology proves that events could be controlled and communicated by a blood-borne chemical, global climate change, human disturbance and endocrine disruption from pollutants are increasingly likely to pose additional stresses that could have a major impact on organisms. Trying to classify these environmental alterations can appear overwhelming because of their complexity. In organisms, hormones play a major role in regulation of various physiological processes, providing an internal communication system and influencing major life processes. Some signals can also help communicate in the wild, such as pheromones secreted outside the body. For example, ants mark their paths with pheromones consisting of volatile hydrocarbons. Some ants lay down an initial trail of pheromones as they return to the nest with food. This trail attracts other ants and serves as a guide. Similarly, all organisms respond to environmental cues that allow them to organize the timing and duration of life history stages that make up their life cycles. We go forward with this idea and explore the behavioral changes due to hormonal fluctuations and environmental stress that influences organisms in - air, water and land.

Humanity is often faced with challenges such as disease, natural disasters and war that cause us pain and suffering. While it is impossible to evade these harsh realities of human life, we can try alleviate some of the suffering through various efforts. Organ donation is one of such endeavour. The organ donation registry tables across the different states of United States of America is cited here as an example whose main purpose is to invite people from all walks of life to literally give a piece of themselves to others. Considering the deficit of organs for transplantation in hospitals, this is indeed a very noble gesture. This is one of the initiatives that should be included in every corner around the world. This is because the value of human life should be protected and maintained and this is one way to ensure that a life is saved and collectively it will be salvation of humanity as a race. It seems as the years pass by the importance of donating or pledging to donate organs has not decreased rather the need has increased and outreach is an essential component of education for “Gift of Life” which needs to be reinforced time and over again.

Diabetes mellitus, it’s not a disease and its group of metabolic disorders characterized by an imbalanced blood sugar level or hyperglycemia over a prolonged period.For in this study diabetes was induced by injection of a single intra-peritoneal dose of Alloxan monohydrate (freshly prepared in 0.1% normal saline). Overnight fasted rats were injected with Alloxan (alloxan; 120mg/kg body wt., i.p) to induce diabetes. Diabetic was confirmed by glucose estimation. Animal with plasma glucose level > 200mg/dl were selected for the study. Diabetic induced Animals were grouped for further study. After 3 days of alloxan induction, treatment was started. Weak preliminary evidence hints that Tylophora might have anti-inflammatory, reduces asthma symptoms, antiallergic, and antispasmodic actions and regulate blood glucose level. Preliminary phytochemical studies revealed the presence of alkaloids, carbohydrates, steroids, saponins, and triterpenes.