This study aims to enhance the solubility and dissolution rate of atorvastatin calcium, a poorly water-soluble drug, by formulating solid dispersions. The objectives include Investigating the impact of different carriers (e.g., polymers, surfactants) on atorvastatin calcium solubility characterizing the physicochemical properties of the prepared solid dispersions (e.g., drug-carrier interactions, crystallinity) Developing and evaluating tablets containing the optimized solid dispersion; and comparing the in vitro drug release profile of the developed tablets with a marketed atorvastatin calcium formulation. The successful development of these solid dispersions could potentially improve the bioavailability and therapeutic efficacy of atorvastatin calcium.